One approach to understanding components in living organisms is to
attempt to create them artificially, using principles of chemistry,
engineering and genetics. A suite of powerful techniques—collectively
referred to as synthetic biology—have been used to produce
self-replicating molecules, artificial pathways in living systems and
organisms bearing synthetic genomes.
In a new twist, John Chaput, a researcher at Arizona
State University’s Biodesign Institute and colleagues at the Department
of Pharmacology, Midwestern University, Glendale, AZ have fabricated an
artificial protein in the laboratory and examined the surprising ways
living cells respond to it.
“If you take a protein that was created in a test
tube and put it inside a cell, does it still function,” Chaput asks.
“Does the cell recognize it? Does the cell just chew it up and spit it...
Friday, 28 December 2012
Thursday, 27 December 2012
New Data Challenge Old Views About Evolution of Early Life
A research team led by biogeochemists at the University of
California, Riverside has tested a popular hypothesis in paleo-ocean
chemistry, and proved it false.
The fossil record indicates that eukaryotes
— single-celled and multicellular organisms with more complex cellular
structures compared to prokaryotes, such as bacteria — show limited
morphological and functional diversity before 800-600 million years ago.
Many researchers attribute the delayed diversification and
proliferation of eukaryotes, which culminated in the appearance of
complex animals about 600 million years ago, to very low levels of the
trace metal zinc in seawater.
As it is for humans, zinc is essential for a wide range of basic
cellular processes. Zinc-binding proteins, primarily located in the
cell nucleus, are involved in the regulation of gene transcription.
Organic-rich shale samples, such...
Thursday, 20 December 2012
GEIC deadline extended to 31st December

GEIC
GBioFin Entrepreneurship and Innovation
Certificate
NOW IT’S YOUR TURN TO
BE THE NEXT KIRAN MAZUMDAR!!!!!!!!!!!
We come across many students who have
lots of business ideas during their graduation days, about opening their own
business and a dream of being the Boss /CEO of their own company. But with time,
these ideas get cornered and a person ends up finding a good job or takes up
higher studies etc, but very few have the courage to start...
TATA First Dot Student Start-up Award
APPEAL
We have been nominated for Tata first dot Student Start-up
Award Powered by NEN
VOTE for us (
GBioFin Biotechnology Services) at Tata first dot to BRING THE CHANGE
Get yourself registered and VOTE for Biotech.
Remember "VOTE" is different from the
"LIKE" option. So do cast your vote. AND BRING THE CHANGE
!!!!!!!
3 Steps to Cast your VOTE :-
1)Click on the link http://tatafirstdot.com/nomination/gbiofin
2)Click on the Thumbs up Option
3)Sign Up and Like again on the FB Link (
confirmation link will be send to your email id)
4) After the Click on the confirmation link your will be able to CAST YOUR VOTE
5) After you VOTE , make sure your Vote is
registered.
- Make sure you VOTE and not just
Like
We have got 4,195 members on Facebook group. We can win this. Please vote.
Come Join Us in our Movement to BRING THE CHANGE !!!!!!!
...
CSIR UGC NET(Life Sciences)
This post is dedicated to all the NET aspirants who will be taking the test this Sunday i.e. the 23rd December 2012.
We hope you are all geared up and ready to rock the test.
CSIR NET exam is really a tough one and thousands of aspirants desire to crack it. It needs a thorough preparation which you all must be done with by now and a well planned strategy for taking the exam.
Here in this post we will be providing you some tips about CSIR UGC NET.
1. The first suggestion to all is to keep a check on the CSIR HRDG website always, even after you have taken the exam.
For instance the timings of the exams was changed as given here.
2. Try doing a lot of question papers of the previous NET exams, as many as possible. This helps in improving your speed which is a crucial factor when one is attempting the questions in very limited time.
In addition to that, it helps in preparing a strategy which you are most likely to follow in your exam to manage your time between questions (not all questions need to be attempted) and obtain the maximum efficiency and as a consequence the maximum marks.
3. Work on your strong topics very exhaustively. Since only 15/20, 35/50 and 25/75 questions need to be done, it will help you to decide the questions quickly thus saving a lot of time. In other words you should have complete knowledge of the topic you are very good at.
4. Never answer the questions randomly. Answer only if you are sure of the answer.
Sometimes categorizing the questions into 3 categories, absolutely sure ones, doubtful ones and the ones with no idea; is helpful. This way you can attempt the first category and only if the required number...
Wednesday, 19 December 2012
Designing Influenza Immunogen
Influenza HA is the primary target of neutralizing antibodies during infection, and its sequence undergoes genetic drift and shift in response to immune pressure. The receptor binding HA1 subunit of HA shows much higher sequence variability relative to the metastable, fusion-active HA2 subunit, presumably because neutralizing antibodies are primarily targeted against the former in natural infection. We have designed an HA2-based immunogen using a protein minimization approach that incorporates designed mutations to destabilize the low pH conformation of HA2. The resulting construct (HA6) was expressed in Escherichia coli and refolded from inclusion bodies. Biophysical studies and mutational analysis of the protein indicate that it is folded into the desired neutral pH conformation competent to bind the broadly neutralizing HA2 directed monoclonal 12D1, not the low pH conformation observed in previous studies. HA6 was highly immunogenic in mice and the mice were protected against lethal challenge by the homologous A/HK/68 mouse-adapted virus. An HA6-like construct from another H3 strain (A/Phil/2/82) also protected mice against A/HK/68 challenge. Regions included in HA6 are highly conserved within a subtype and are fairly well conserved within a clade. Targeting the highly conserved HA2 subunit with a bacterially produced immunogen is a vaccine strategy that may aid in pandemic preparedness.
Read the full study here.
A summary is given here.
...
Sunday, 2 December 2012
Hiyoshi Internship Program 2013
Hiyoshi Corporation, Omihachiman, Japan and ABK-AOTS DOSOKAI, Tamilnadu Centre are jointly organizing two months stipendiary International Internship Program’2013 at Japan for three students from the Engineering Colleges / Universities of India.
The students can be from Biotechnology, Environmental Science &
Chemical Engineering and they should have consistently scored 75% of marks throughout.
Preferences will be given to those students who are having knowledge in basic Japanese Language skill.
Students who are perusing Third Year of Engineering or 1st yr of post graduation can apply for this program
Terms & Conditions and Application Form for the Training at Hiyoshi Corporation, Japan is in below link.
Internship details
Application form
...
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