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Thursday 21 November 2013

Fredrick Sanger, the two-times Nobel Laureate died on 19th November 2013.

The only person to have won the prestigious Nobel Prize, the highest honor in Science, in the field of Chemistry, Fredrick Sanger passed away on 19th November 2013. Fredrick Sanegr was a British Biochemist who is one among the four to have won the Nobel Prize twice and the only person to have won it in Chemistry twice. He was born on 13th August 1918 in Rendcomb, Gloucertershire, England. 
He was a good student since the beginning and scored a good result in the School Certificate Examination. He then joined the St. John's College, Cambridge as an undergraduate in the field of natural sciences in the year 1936.He completed his Part 1 in three years. For part 2 he chose Biochemistry. He graduated in the year 1940 (December). He, later on, began his Ph.D. in the same year on the topic of obtaining edible protein from grass under the guidance of N.W. "Bill" Pirie and Albert Neuberger. He changed his research topic and finally his thesis was about "The metabolism of the amino acid lysine in the animal body" and was awarded his Doctorate in 1943.
                          
Sanger later on, extensively worked on the sequencing of the structure of the protein Insulin. For his outstanding research, he was presented with the Nobel Prize in Chemistry in 1958. Continuing his flair for research he worked in the field of genetics and revolutionized this area with his exemplary work on how to sequence DNA and thus, provided with a way to understand Genetics more closely. 
Solving the problem of DNA sequencing became a new goal of his work in protein sequencing. Sanger initially investigated ways to sequence RNA because it was smaller. Eventually, this led to techniques that were applicable to DNA and finally to the dideoxy method most commonly used in sequencing reactions today. In this method, stretches of 500-800 bases at a time can be read. This brought him his second Nobel Prize in the year 1980.
Sanger married Margaret Joan Howe in 1940.
He has been presented with innumerable awards for his breakthrough work in the field of science and revolutionizing Biotechnology. Some of the awards are:
  • Corday–Morgan Medal – 1951
  • Fellow of the Royal Society – 1954
  • Nobel Prize in Chemistry – 1958, 1980
  • Commander of the Order of the British Empire – 1963
  • Royal Medal – 1969
  • Gairdner Foundation International Award – 1971
  • William Bate Hardy Prize – 1976
  •  Copley Medal – 1977
  • G.W. Wheland Award – 1978
  • Louisa Gross Horwitz Prize of Columbia University – 1979
  • Albert Lasker Award for Basic Medical Research – 1979
  • Order of the Companions of Honour – 1981
  •  Corresponding Fellow of the Australian Academy of Science – 1982
  • Order of Merit (Commonwealth) – 1986
  •  Association of Biomolecular Resource Facilities Award – 1994