PhD fellowship in Genomic Engineering of Human Stem Cells at University of Copenhagen
- Stem Cells and Embryology Group :Induced pluripotent stem cells (iPSCs) from humans and pigs are used to e.g. establish better therapies for neuro-degenerative diseases and other neurological diseases by the establishment of patient-specific in-vitro nerve cell models and genetically modified animal models. The group has an open 3-year PhD position in iPSCs comencing on 1 December 2013 or as soon as possible thereafter.
- Project description : Genetic correction and characterization of induced pluripotent stem cells (iPSCs) derived from patients suffering from Alzheimer´s disease or Frontotemporal dementia (FTP): proof of concept for potential cell therapy and discovery of novel mechanisms underlying the disease. The project will include correction of an in-vitro human disease model using TALEN nucleases. The cell lines will be characterized for pathology associated with the disease. In-vitro investigation of the roles of glycoproteins and other related studies relating to glycosylation will be conducted. Genetic correction and transplantation of stem cells into a mouse model of either Alzheimer´s disease or frontotemporal dementia will be performed.
- Qualifications : We are seeking a highly motivated and qualified Master student that has a tertiary degree from a Science, Biotechnology, Genetics or Medicine discipline. We are seeking a person that has excelled in university grades and produced a Master´s thesis on a relevant topic to the project description. First author publications are deemed favorable
- culture of pluripotent mammalian stem cells
- gene modification techniques
- molecular cloning/plasmid design
- TALEN/ZFN technology
- handling of rodents
- background in neurobiology
- culture of human induced pluripotent stem cells
- experience in stem cell differentiation into neurons
- experience in analysis of TAU pathology
- knowledge on neurodegenerative diseases (focus on Frontotemporal dementia and alzheimer´s
- glycobiology
- Manage and carry through the research project above
- Take PhD courses
- Write scientific articles and your PhD thesis
- Participate in congresses
- Teach and disseminate your research
- The research group is located on the Frederiksberg campus, close to the center of Copenhagen. We are an interdisciplinary research group with national as well as international collaborators and visits to the partners are organized when necessary.
- Our research environment is highly international and stimulating. We frequently
- organize seminars, workshops, PhD summer schools with international speakers and have retreats with our international collaborators.
- The position will be filled according to the agreement between the Danish Ministry of Finance and the Danish Confederation of Professional Associations. The salary depends on seniority, and individual supplements can be negotiated depending on qualifications. The post is covered by the Protocol on Job Structure.
- It is a prerequisite that the PhD candidate is enrolled as a PhD student at the Faculty of Health and Medical Sciences, University of Copenhagen, according to the rules stipulated in "Executive order no 18 of 14 January 2008"
- Scientific content, please contact : Dr. Vanessa Hall, e-mail vh@sund.ku.dk, phone +45 3533 2512.
- Application procedure and formalities please contact : Administrative Officer, Marie-Louise Rosenlund, e-mail: mln@sund.ku.dk, phone: +45 3533 2898.
- Deadline : 31.10.13
Required : Experience in most of the following:
Desirable : Experience in :
Position : The position is available for a 3-year period for applicants holding a relevant master´s degree. The successful applicant will be employed at University of Copenhagen in accordance with the collective agreement between AC and the Danish State.
Job description : Your key tasks as a PhD student are:
Place of employment :
Terms of employment :
For further information please contact :
